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Article

RASSF1A methylation may have two biological roles in neuroblastoma tumorigenesis depending on the ploidy status and age of patients.

Cancer letters - 28 Jun 2014

Haruta Masayuki, Kamijo Takehiko, Nakagawara Akira, Kaneko Yasuhiko

Abstract excerpt

RASSF1A methylation was frequent in neuroblastomas found in infants by mass-screening or infants and children diagnosed clinically, whereas CASP8 and DCR2 methylation was only frequent in tumors in children. When classified according to the ploidy status, RASSF1A and PCDHB methylation was only associated with MYCN amplification and poor outcomes in infants with a clinically diagnosed diploid, not triploid tumor....

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Source

Identifiers

PMID: 24680815
DOI: 10.1016/j.canlet.2014.03.022

Genes

MYCN
CASP8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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