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Article

Epigenetic alterations differ in phenotypically distinct human neuroblastoma cell lines.

BMC cancer - 14 Jun 2010

Yang Qiwei, Tian Yufeng, Ostler Kelly R, Chlenski Alexandre, Guerrero Lisa J, Salwen Helen R, Godley Lucy A, Cohn Susan L

Abstract excerpt

BACKGROUND: Epigenetic aberrations and a CpG island methylator phenotype have been shown to be associated with poor outcomes in children with neuroblastoma (NB). Seven cancer related genes (THBS-1, CASP8, HIN-1, TIG-1, BLU, SPARC, and HIC-1) that have been shown to have epigenetic changes in adult cancers and play important roles in the regulation of angiogenesis, tumor growth, and apoptosis were analyzed to...

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Source

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Identifiers

PMID: 20546602
DOI: 10.1186/1471-2407-10-286
PMCID: PMC2897803

Genes

CASP8
SPARC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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