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Article

Methylation of tumor‐suppressor genes in neuroblastoma: The RASSF1A gene is almost always methylated in primary tumors

14 Jun 2007

Abstract excerpt

BACKGROUND: Currently, the best characterized genetic aberration in neuroblastoma (NB) is MYCN amplification, which has been clearly related to prognosis. In the present study, we investigated whether specific epigenetic alterations are associated with stage of disease. PROCEDURE: Sixty-two NBs (45 primary tumors and 17 NBs at relapse) were studied in terms of the methylation status of 19 genes (p15INK4a,...

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PMID: 17570703
DOI: 10.1002/pbc.21279

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