Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The RASSF gene family members RASSF5, RASSF6 and RASSF7 show frequent DNA methylation in neuroblastoma

13 Jun 2012

Abstract excerpt

BACKGROUND: Hypermethylation of promotor CpG islands is a common mechanism that inactivates tumor suppressor genes in cancer. Genes belonging to the RASSF gene family have frequently been reported as epigenetically silenced by promotor methylation in human cancers. Two members of this gene family, RASSF1A and RASSF5A have been reported as methylated in neuroblastoma. Data from our previously performed genome-wide...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related gene regulation
Share to Epigenetics and DNA Methylation
Share to Neuroblastoma Research and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22695170
DOI: 10.1186/1476-4598-11-40

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The RASSF gene family members RASSF5, RASSF6 and RASSF7 show frequent DNA methylation in neuroblastomaPMID 22695170Read ↗

Association of Epigenetic Inactivation of RASSF1A with Poor Outcome in Human NeuroblastomaSemantic proximity Read ↗

Methylation of tumor‐suppressor genes in neuroblastoma: The RASSF1A gene is almost always methylated in primary tumorsSemantic proximity Read ↗

RASSF1A hypermethylation in pretreatment serum DNA of neuroblastoma patients: a prognostic markerSemantic proximity Read ↗

DNA Hypomethylation Affects Cancer-Related Biological Functions and Genes Relevant in Neuroblastoma PathogenesisSemantic proximity Read ↗

Clustering of Gene Hypermethylation Associated With Clinical Risk Groups in NeuroblastomaSemantic proximity Read ↗

Ubiquitous aberrant RASSF1A promoter methylation in childhood neoplasia.Semantic proximity Read ↗

Promoter Methylation Status of Ras-Association Domain Family Member in PheochromocytomaSemantic proximity Read ↗

RASSF1A methylation may have two biological roles in neuroblastoma tumorigenesis depending on the ploidy status and age of patients.Semantic proximity Read ↗

Genome-wide promoter methylation analysis in neuroblastoma identifies prognostic methylation biomarkersSemantic proximity Read ↗

CpG Island Methylator Phenotype Is a Strong Determinant of Poor Prognosis in NeuroblastomasSemantic proximity Read ↗

Aberrant promoter methylation and silencing of the RASSF1A gene in pediatric tumors and cell lines.Semantic proximity Read ↗

The novel RASSF6 and RASSF10 candidate tumour suppressor genes are frequently epigenetically inactivated in childhood leukaemiasSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.