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Article

GRN Missense Variants and Familial Alzheimer's Disease: Two Case Reports.

Journal of Alzheimer's disease : JAD - 1 Jan 2023

Ingannato Assunta, Bessi Valentina, Chiari Annalisa, Salvatori Davide, Bagnoli Silvia, Bedin Roberta, Ferrari Camilla, Sorbi Sandro, Nacmias Benedetta

Abstract excerpt

BACKGROUND: Progranulin protein (GRN) is a growth factor, encoded by the GRN (Granulin precursor) gene, involved in several functions including inflammation, wound repair, signal transduction, proliferation, and tumorigenesis. Mutations in GRN gene are usually the genetic etiology of frontotemporal dementia (FTD), but different studies reported GRN mutations in Alzheimer 's disease (AD) patients. OBJECTIVE: Here,...

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PMID: 37899057
DOI: 10.3233/JAD-230689

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