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Article

Coronary Disease-Associated Gene TCF21 Inhibits Smooth Muscle Cell Differentiation by Blocking the Myocardin-Serum Response Factor Pathway.

Circulation research - 14 Feb 2020

Nagao Manabu, Lyu Qing, Zhao Quanyi, Wirka Robert C, Bagga Joetsaroop, Nguyen Trieu, Cheng Paul, Kim Juyong Brian, Pjanic Milos, Miano Joseph M, Quertermous Thomas

Abstract excerpt

RATIONALE: The gene encoding TCF21 (transcription factor 21) has been linked to coronary artery disease risk by human genome-wide association studies in multiple racial ethnic groups. In murine models, Tcf21 is required for phenotypic modulation of smooth muscle cells (SMCs) in atherosclerotic tissues and promotes a fibroblast phenotype in these cells. In humans, TCF21 expression inhibits risk for coronary artery...

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Identifiers

PMID: 31815603
DOI: 10.1161/CIRCRESAHA.119.315968
PMCID: PMC7274203

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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