Novel polymorphism in the A4 region of the amyloid precursor protein gene in a patient without Alzheimer's disease

Abstract excerpt

<h3>ABSTRACT</h3> The degree to which adaptation in recent human evolution shapes genetic variation remains controversial. This is in part due to the limited evidence in humans for classic “hard selective sweeps,” wherein a novel beneficial mutation rapidly sweeps through a population to fixation. However, positive selection may often proceed via “soft sweeps” acting on mutations already present within a...

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