Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of genetic variations on MHC class I antigen-processing genes in human cancer and viral-mediated diseases.

Molecular immunology - 1 Sept 2019

D'Alicandro Valerio, Romania Paolo, Melaiu Ombretta, Fruci Doriana

Abstract excerpt

Cytotoxic T lymphocytes constantly monitor peptide-MHC class I complexes on the cell surface to eliminate transformed and virally infected cells expressing peptides derived from abnormal proteins. The generation of antigenic peptides and their loading on MHC class I molecules is a multistep process involving different molecules that constitute the so-called antigen processing and presentation machinery (APM). To...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigen Presentation
Share to Genes, MHC Class I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Histocompatibility Antigens Class I

Share to Neoplasms

Share to Peptides

Share to T-Lymphocytes, Cytotoxic

Share to Virus Diseases

Source

Identifiers

PMID: 29625843
DOI: 10.1016/j.molimm.2018.03.024

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of genetic variations on MHC class I antigen-processing genes in human cancer and viral-mediated diseases.PMID 29625843Read ↗

The link between MHC class I abnormalities of tumors, oncogenes, tumor suppressor genes, and transcription factors.Semantic proximity Read ↗

Variations in MHC class I antigen presentation and immunopeptidome selection pathwaysSemantic proximity Read ↗

Individual HLA heterogeneity and its implications for cellular immune evasion in cancer and beyondSemantic proximity Read ↗

Defects in antigen processing and presentation: mechanisms, immune evasion and implications for cancer vaccine developmentSemantic proximity Read ↗

Genetics of antigen processing and presentationSemantic proximity Read ↗

HLA Genes: A Hallmark of Functional Genetic Variation and Complex Evolution.Semantic proximity Read ↗

MHC class I chain-related A: Polymorphism, regulation and therapeutic value in cancer.Semantic proximity Read ↗

The Transporter Associated With Antigen Processing (TAP): Structural Integrity, Expression, Function, and Its Clinical RelevanceSemantic proximity Read ↗

Distinct mutational processes shape selection of MHC class I and class II mutations across primary and metastatic tumors.Semantic proximity Read ↗

Distinct mutational processes shape selection of MHC class I and class II mutations across primary and metastatic tumorsSemantic proximity Read ↗

HLA class I restricted epitopes prediction of common tumor antigens in white and East Asian populations: Implication on antigen selection for cancer vaccine design.Semantic proximity Read ↗

A Role for Naturally Occurring Alleles of Endoplasmic Reticulum Aminopeptidases in Tumor Immunity and Cancer Pre-DispositionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.