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Plasmodium falciparumantigenic variation: relationships between widespread endothelial activation, parasite PfEMP1 expression and severe malaria

28 Mar 2014

Abstract excerpt

BACKGROUND: Plasmodium falciparum erythrocyte membrane protein 1(PfEMP1) is a family of variant surface antigens (VSA) that mediate the adhesion of parasite infected erythrocytes to capillary endothelial cells within host tissues. Opinion is divided over the role of PfEMP1 in the widespread endothelial activation associated with severe malaria. In a previous study we found evidence for differential associations...

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PMID: 24674301
DOI: 10.1186/1471-2334-14-170

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