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Article

Identification of a Region of PfEMP1 That Mediates Adherence of Plasmodium falciparum Infected Erythrocytes to CD36: Conserved Function With Variant Sequence

1 Nov 1997

Abstract excerpt

Adherence of mature parasitized erythrocytes (PE) of Plasmodium falciparum to microvascular endothelial cells contributes directly to the virulence and pathology of this human malaria. The malarial variant antigen, P falciparum erythrocyte membrane protein 1 (PfEMP1), has been implicated as the PE receptor for CD36 on endothelial cells. We identified the region of PfEMP1 that mediates adherence of PE to CD36 and...

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PMID: 9345064
DOI: 10.1182/blood.v90.9.3766

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Related research

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Research trail→

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Identification of a Region of PfEMP1 That Mediates Adherence of Plasmodium falciparum Infected Erythrocytes to CD36: Conserved Function With Variant SequencePMID 9345064Read ↗

Cloning the P. falciparum gene encoding PfEMP1, a malarial variant antigen and adherence receptor on the surface of parasitized human erythrocytesSemantic proximity Read ↗

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Structure-Guided Identification of a Family of Dual Receptor-Binding PfEMP1 that Is Associated with Cerebral MalariaSemantic proximity Read ↗

Divergent binding sites on intercellular adhesion molecule‐1 (ICAM‐1) for variant Plasmodium falciparum isolatesSemantic proximity Read ↗

Structural conservation despite huge sequence diversity allows EPCR binding by the PfEMP1 family implicated in severe childhood malaria.Semantic proximity Read ↗

Widespread functional specialization of <i>Plasmodium falciparum</i> erythrocyte membrane protein 1 family members to bind CD36 analysed across a parasite genomeSemantic proximity Read ↗

Common virulence gene expression in adult first-time infected malaria patients and severe casesSemantic proximity Read ↗

The role of PfEMP1 adhesion domain classification in Plasmodium falciparum pathogenesis researchSemantic proximity Read ↗

Investigating the host binding signature on the Plasmodium falciparum PfEMP1 protein family.Semantic proximity Read ↗

Gene expression profiling of malaria parasites reveals common virulence gene expression in adult first-time infected patients and severe casesSemantic proximity Read ↗

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