Article
Specific receptor usage in Plasmodium falciparum cytoadherence is associated with disease outcome.
PloS one - 3 Mar 2011
Ochola Lucy B, Siddondo Bethsheba R, Ocholla Harold, Nkya Siana, Kimani Eva N, Williams Thomas N, Makale Johnstone O, Liljander Anne, Urban Britta C, Bull Pete C, Szestak Tadge, Marsh Kevin, Craig Alister G
Abstract excerpt
Our understanding of the basis of severe disease in malaria is incomplete. It is clear that pathology is in part related to the pro-inflammatory nature of the host response but a number of other factors are also thought to be involved, including the interaction between infected erythrocytes and endothelium. This is a complex system involving several host receptors and a major parasite-derived variant antigen...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.