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Article

Cancer stem cells in the development of liver cancer.

The Journal of clinical investigation - 1 May 2013

Yamashita Taro, Wang Xin Wei

Abstract excerpt

Liver cancer is an aggressive disease with a poor outcome. Several hepatic stem/progenitor markers are useful for isolating a subset of liver cells with stem cell features, known as cancer stem cells (CSCs). These cells are responsible for tumor relapse, metastasis, and chemoresistance. Liver CSCs dictate a hierarchical organization that is shared in both organogenesis and tumorigenesis. An increased...

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Identifiers

PMID: 23635789
DOI: 10.1172/JCI66024
PMCID: PMC3635728

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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