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Article

CD271 Defines a Stem Cell-Like Population in Hypopharyngeal Cancer

23 Apr 2013

Abstract excerpt

Cancer stem cells contribute to the malignant phenotypes of a variety of cancers, but markers to identify human hypopharyngeal cancer (HPC) stem cells remain poorly understood. Here, we report that the CD271(+) population sorted from xenotransplanted HPCs possesses an enhanced tumor-initiating capability in immunodeficient mice. Tumors generated from the CD271(+) cells contained both CD271(+) and CD271(-) cells,...

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PMID: 23626764
DOI: 10.1371/journal.pone.0062002

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