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Article

The nickel dose-response relationship by filaggrin genotype (FLG).

Contact dermatitis - 1 Jul 2014

Ross-Hansen Katrine, Johansen Jeanne D, Vølund Aage, Menné Torkil, Thyssen Jacob P

Abstract excerpt

BACKGROUND: On skin contact, nickel accumulates in the stratum corneum, where it is probably bound to proteins and amino acids. One probable contributor is filaggrin, which binds nickel avidly. Filaggrin gene (FLG) null mutations lead to a complete lack of filaggrin production from the affected allele, and have been associated with an increased risk of nickel contact sensitization in German and Danish adults....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24673390
DOI: 10.1111/cod.12228

Genes

FLG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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