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Article

Filaggrin Polymorphisms and the Uptake of Chemicals through the Skin-A Human Experimental Study.

Environmental health perspectives - 1 Jan 2021

Rietz Liljedahl Emelie, Johanson Gunnar, Korres de Paula Helena, Faniband Moosa, Assarsson Eva, Littorin Margareta, Engfeldt Malin, Lidén Carola, Julander Anneli, Wahlberg Karin, Lindh Christian, Broberg Karin

Abstract excerpt

BACKGROUND: The filaggrin protein is important for skin barrier structure and function. Loss-of-function (null) mutations in the filaggrin gene FLG may increase dermal absorption of chemicals. OBJECTIVE: The objective of the study was to clarify if dermal absorption of chemicals differs depending on FLG genotype. METHOD: We performed a quantitative real-time polymerase chain reaction (qPCR)-based genetic screen...

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Identifiers

PMID: 33439052
DOI: 10.1289/EHP7310
PMCID: PMC7805408

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