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Article

Lysine 27 ubiquitination of the mitochondrial transport protein Miro is dependent on serine 65 of the Parkin ubiquitin ligase.

The Journal of biological chemistry - 23 May 2014

Birsa Nicol, Norkett Rosalind, Wauer Tobias, Mevissen Tycho E T, Wu Hsiu-Chuan, Foltynie Thomas, Bhatia Kailash, Hirst Warren D, Komander David, Plun-Favreau Helene, Kittler Josef T

Abstract excerpt

Mitochondrial transport plays an important role in matching mitochondrial distribution to localized energy production and calcium buffering requirements. Here, we demonstrate that Miro1, an outer mitochondrial membrane (OMM) protein crucial for the regulation of mitochondrial trafficking and distribution, is a substrate of the PINK1/Parkin mitochondrial quality control system in human dopaminergic neuroblastoma...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24671417
DOI: 10.1074/jbc.M114.563031
PMCID: PMC4031514

Genes

PINK1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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Lysine 27 ubiquitination of the mitochondrial transport protein Miro is dependent on serine 65 of the Parkin ubiquitin ligase.PMID 24671417Read ↗

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Parkin‐mediated ubiquitylation redistributes MITOL/March5 from mitochondria to peroxisomesSemantic proximity Read ↗

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