Article
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1.
Nature cell biology - 1 Feb 2010
Geisler Sven, Holmström Kira M, Skujat Diana, Fiesel Fabienne C, Rothfuss Oliver C, Kahle Philipp J, Springer Wolfdieter
Abstract excerpt
Parkinson's disease is the most common neurodegenerative movement disorder. Mutations in PINK1 and PARKIN are the most frequent causes of recessive Parkinson's disease. However, their molecular contribution to pathogenesis remains unclear. Here, we reveal important mechanistic steps of a PINK1/Parkin-directed pathway linking mitochondrial damage, ubiquitylation and autophagy in non-neuronal and neuronal cells....
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