Article
Identification of a characteristic copy number alteration profile by high-resolution single nucleotide polymorphism arrays associated with metastatic sporadic colorectal cancer.
Cancer - 1 Jul 2014
González-González María, Fontanillo Celia, Abad María M, Gutiérrez María L, Mota Ines, Bengoechea Oscar, Santos-Briz Ángel, Blanco Oscar, Fonseca Emilio, Ciudad Juana, Fuentes Manuel, De Las Rivas Javier, Alcazar José A, García Jacinto, Muñoz-Bellvis Luís, Orfao Alberto, Sayagués José M
Abstract excerpt
BACKGROUND: Metastatic dissemination is the most frequent cause of death in patients with sporadic colorectal cancer (sCRC). It is believed that the metastatic process is related at least in part to a specific background of genetic alterations accumulated in cells from primary tumors, and the ability to detect such alterations is critical for the identification of patients with sCRC who are at risk of developing...
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