Article
Patterns of gene expression and copy-number alterations in von-hippel lindau disease-associated and sporadic clear cell carcinoma of the kidney.
Cancer research - 1 Jun 2009
Beroukhim Rameen, Brunet Jean-Philippe, Di Napoli Arianna, Mertz Kirsten D, Seeley Apryle, Pires Maira M, Linhart David, Worrell Robert A, Moch Holger, Rubin Mark A, Sellers William R, Meyerson Matthew, Linehan W Marston, Kaelin William G, Signoretti Sabina
Abstract excerpt
Recent insights into the role of the von-Hippel Lindau (VHL) tumor suppressor gene in hereditary and sporadic clear-cell renal cell carcinoma (ccRCC) have led to new treatments for patients with metastatic ccRCC, although virtually all patients eventually succumb to the disease. We performed an integrated, genome-wide analysis of copy-number changes and gene expression profiles in 90 tumors, including both...
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