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FLT1 and other candidate fetal haemoglobin modifying loci in sickle cell disease in African ancestries

1 Mar 2025

Abstract excerpt

Known fetal haemoglobin (HbF)-modulating loci explain 10–24% variation of HbF level in Africans with Sickle Cell Disease (SCD), compared to 50% among Europeans. Here, we report fourteen candidate loci from a genome-wide association study (GWAS) of HbF level in patients with SCD from Cameroon, Tanzania, and the United States of America. We present results of cell-based experiments for FLT1 candidate, demonstrating...

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PMID: 40025045
DOI: 10.1038/s41467-025-57413-5

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