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Article

Overexpression of Wilms tumor 1 gene as a negative prognostic indicator in acute myeloid leukemia.

PloS one - 1 Jan 2014

Lyu Xiaodong, Xin Yaping, Mi Ruihua, Ding Jing, Wang Xianwei, Hu Jieying, Fan Ruihua, Wei Xudong, Song Yongping, Zhao Richard Y

Abstract excerpt

Chromosomal aberrations are useful in assessing treatment options and clinical outcomes of acute myeloid leukemia (AML) patients. However, 40 ∼ 50% of the AML patients showed no chromosomal abnormalities, i.e., with normal cytogenetics aka the CN-AML patients. Testing of molecular aberrations such as FLT3 or NPM1 can help to define clinical outcomes in the CN-AML patients but with various successes. Goal of this...

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Identifiers

PMID: 24667279
DOI: 10.1371/journal.pone.0092470
PMCID: PMC3965428

Genes

FLT3
NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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