Wilms' tumor 1 gene mutations independently predict poor outcome in adults with cytogenetically normal acute myeloid leukemia: a cancer and leukemia group B study.

doi:10.1200/JCO.2007.15.2058

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Article

Wilms' tumor 1 gene mutations independently predict poor outcome in adults with cytogenetically normal acute myeloid leukemia: a cancer and leukemia group B study.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Oct 2008

Paschka Peter, Marcucci Guido, Ruppert Amy S, Whitman Susan P, Mrózek Krzysztof, Maharry Kati, Langer Christian, Baldus Claudia D, Zhao Weiqiang, Powell Bayard L, Baer Maria R, Carroll Andrew J, Caligiuri Michael A, Kolitz Jonathan E, Larson Richard A, Bloomfield Clara D

Abstract excerpt

PURPOSE: To analyze the prognostic impact of Wilms' tumor 1 (WT1) gene mutations in cytogenetically normal acute myeloid leukemia (CN-AML). PATIENTS AND METHODS We studied 196 adults younger than 60 years with newly diagnosed primary CN-AML, who were treated similarly on Cancer and Leukemia Group B (CALGB) protocols 9621 and 19808, for WT1 mutations in exons 7 and 9. The patients also were assessed for the...

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Identifiers

PMID: 18559874
DOI: 10.1200/JCO.2007.15.2058
PMCID: PMC2653131

Genes

FLT3
NPM1
ERG
BAALC

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