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Wilms' tumor gene 1 in hematological malignancies: friend or foe?

Hematology (Amsterdam, Netherlands) - 1 Dec 2023

Wu Jie, Yan Hui, Xiang Chunli

Abstract excerpt

Wilms' tumor gene 1 (WT1) is a transcription and post-translational factor that has a crucial role in the biological and pathological processes of several human malignancies. For hematological malignancies, WT1 overexpression or mutation has been found in leukemia and myelodysplastic syndrome. About 70-90% of acute myeloid leukemia patients showed WT1 overexpression, and 6-15% of patients carried WT1 mutations....

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PMID: 37668240
DOI: 10.1080/16078454.2023.2254557

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