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Article

TAp73 is essential for germ cell adhesion and maturation in testis

24 Mar 2014

Abstract excerpt

A core evolutionary function of the p53 family is to protect the genomic integrity of gametes. However, the role of p73 in the male germ line is unknown. Here, we reveal that TAp73 unexpectedly functions as an adhesion and maturation factor of the seminiferous epithelium orchestrating spermiogenesis. TAp73 knockout (TAp73KO) and p73KO mice, but not ΔNp73KO mice, display a "near-empty seminiferous tubule"...

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Identifiers

PMID: 24662569
DOI: 10.1083/jcb.201306066

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