Article
The p63 C-terminus is essential for murine oocyte integrity.
Nature communications - 15 Jan 2021
Lena Anna Maria, Rossi Valerio, Osterburg Susanne, Smirnov Artem, Osterburg Christian, Tuppi Marcel, Cappello Angela, Amelio Ivano, Dötsch Volker, De Felici Massimo, Klinger Francesca Gioia, Annicchiarico-Petruzzelli Margherita, Valensise Herbert, Melino Gerry, Candi Eleonora
Abstract excerpt
The transcription factor p63 mediates distinct cellular responses, primarily regulating epithelial and oocyte biology. In addition to the two amino terminal isoforms, TAp63 and ΔNp63, the 3'-end of p63 mRNA undergoes tissue-specific alternative splicing that leads to several isoforms, including p63α, p63β and p63γ. To investigate in vivo how the different isoforms fulfil distinct functions at the cellular and...
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