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p63 the guardian of human reproduction

11 Dec 2012

Abstract excerpt

p63 is a transcriptional factor implicated in cancer and development. The presence in TP63 gene of alternative promoters allows expression of one isoform containing the N-terminal transactivation domain (TA isoform) and one N-terminal truncated isoform (ΔN isoform). Complete ablation of all p63 isoforms produced mice with fatal developmental abnormalities, including lack of epidermal barrier, limbs and other...

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PMID: 23165243
DOI: 10.4161/cc.22819

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