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Article

Apolipoprotein E-deficient mice are susceptible to the development of acute lung injury.

Respiration; international review of thoracic diseases - 1 Jan 2014

Yamashita Cory M, Fessler Michael B, Vasanthamohan Lakshman, Lac Joanne, Madenspacher Jennifer, McCaig Lynda, Yao Lijuan, Wang Lefeng, Puntorieri Valeria, Mehta Sanjay, Lewis Jim F, Veldhuizen Ruud A W

Abstract excerpt

BACKGROUND: Apolipoprotein E (apoE) has been shown to play a pivotal role in the development of cardiovascular disease, attributable to its function in lipid trafficking and immune modulating properties; however, its role in modulating inflammation in the setting of acute lung injury (ALI) is unknown. OBJECTIVE: To determine whether apoE-deficient mice (apoE-/-) are more susceptible to ALI compared to wild-type...

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Identifiers

PMID: 24662316
DOI: 10.1159/000358438
PMCID: PMC4659709

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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