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Article

Paigen diet-fed apolipoprotein E knockout mice develop severe pulmonary hypertension in an interleukin-1-dependent manner.

The American journal of pathology - 1 Oct 2011

Lawrie Allan, Hameed Abdul G, Chamberlain Janet, Arnold Nadine, Kennerley Aneurin, Hopkinson Kay, Pickworth Josephine, Kiely David G, Crossman David C, Francis Sheila E

Abstract excerpt

Inflammatory mechanisms are proposed to play a significant role in the pathogenesis of pulmonary arterial hypertension (PAH). Previous studies have described PAH in fat-fed apolipoprotein E knockout (ApoE(-/-)) mice. We have reported that signaling in interleukin-1-receptor-knockout (IL-1R1(-/-)) mice leads to a reduction in diet-induced systemic atherosclerosis. We subsequently hypothesized that double-null...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21835155
DOI: 10.1016/j.ajpath.2011.06.037
PMCID: PMC3181351

Genes

PAH

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