Article
Mutations in epigenetic regulators including SETD2 are gained during relapse in paediatric acute lymphoblastic leukaemia.
Nature communications - 24 Mar 2014
Mar Brenton G, Bullinger Lars B, McLean Kathleen M, Grauman Peter V, Harris Marian H, Stevenson Kristen, Neuberg Donna S, Sinha Amit U, Sallan Stephen E, Silverman Lewis B, Kung Andrew L, Lo Nigro Luca, Ebert Benjamin L, Armstrong Scott A
Abstract excerpt
Relapsed paediatric acute lymphoblastic leukaemia (ALL) has high rates of treatment failure. Epigenetic regulators have been proposed as modulators of chemoresistance, here, we sequence genes encoding epigenetic regulators in matched diagnosis-remission-relapse ALL samples. We find significant enrichment of mutations in epigenetic regulators at relapse with recurrent somatic mutations in SETD2, CREBBP, MSH6,...
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