Article
The retinoblastoma gene: a prototypic and multifunctional tumor suppressor.
Experimental cell research - 10 Mar 2001
Zheng L, Lee W H
Abstract excerpt
Genome instability has been implicated in the generation of multiple somatic mutations that underlie cancer. Germline mutation in the retinoblastoma (RB) gene leads to tumor formation in both human and experimental animal models, and reintroduction of wild-type RB is able to suppress neoplastic phenotypes. Rb governs the passage of cells through the G1 phase-restriction point and this control is lost in most...
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