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Article

Rab5 is required for Caveolin-1-enhanced Rac1 activation, migration and invasion of metastatic cancer cells

1 Jan 2014

Abstract excerpt

Rab5 is a small GTPase that regulates early endosome trafficking and other cellular processes, including cell adhesion and migration. Specifically, Rab5 promotes Rac1 activation and cancer cell migration, but little is known about the upstream regulators of Rab5. We have previously shown that the scaffolding protein Caveolin-1 (CAV1) promotes Rac1 activation and migration of cancer cells. Here, we hypothesized...

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PMID: 24659799
DOI: 10.1242/jcs.141689

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