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Article

E-cadherin determines Caveolin-1 tumor suppression or metastasis enhancing function in melanoma cells.

Pigment cell & melanoma research - 1 Jul 2013

Lobos-González Lorena, Aguilar Lorena, Diaz Jorge, Diaz Natalia, Urra Hery, Torres Vicente A, Silva Veronica, Fitzpatrick Christopher, Lladser Alvaro, Hoek Keith S, Leyton Lisette, Quest Andrew F G

Abstract excerpt

The role of caveolin-1 (CAV1) in cancer is highly controversial. CAV1 suppresses genes that favor tumor development, yet also promotes focal adhesion turnover and migration of metastatic cells. How these contrasting observations relate to CAV1 function in vivo is unclear. Our previous studies implicate E-cadherin in CAV1-dependent tumor suppression. Here, we use murine melanoma B16F10 cells, with low levels of...

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Identifiers

PMID: 23470013
DOI: 10.1111/pcmr.12085
PMCID: PMC3695072

Genes

CAV1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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