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Article

Involvement of the TGFβ pathway in the regulation of α<sub>5</sub>β<sub>1</sub> integrins by caveolin‐1 in human glioblastoma

7 Sept 2011

Abstract excerpt

Caveolin-1 plays a crucial role in the development of cancer and its progression. We previously reported that glioblastoma cells expressing low levels of caveolin-1 exerted a more aggressive phenotype than cells expressing high levels. Such phenotype was due to the induction of α(5) β(1) integrin subsequent to the depletion of caveolin-1. Caveolin-1 was identified as a transcriptional repressor of α(5) β(1)...

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PMID: 21901744
DOI: 10.1002/ijc.26415

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