HLA-A31- and HLA-Aw68-restricted cytotoxic T cell responses to a single hepatitis B virus nucleocapsid epitope during acute viral hepatitis.

doi:10.1084/jem.177.3.751

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

HLA-A31- and HLA-Aw68-restricted cytotoxic T cell responses to a single hepatitis B virus nucleocapsid epitope during acute viral hepatitis.

The Journal of experimental medicine - 1 Mar 1993

Missale G, Redeker A, Person J, Fowler P, Guilhot S, Schlicht H J, Ferrari C, Chisari F V

Abstract excerpt

We have recently developed the technology to identify and characterize the human histocompatibility leukocyte antigen (HLA) class I-restricted, CD8+ cytotoxic T lymphocyte (CTL) response to hepatitis B virus (HBV)-encoded antigens in patients with acute viral hepatitis. CTL are expanded in vitro...

Topics

Acute Disease
Alleles
Amino Acid Sequence
Capsid
Cell Line
Epitopes
Female
HLA-A Antigens
Hepatitis B
Hepatitis B Antigens
Hepatitis B Core Antigens
Hepatitis B virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Male

Molecular Sequence Data

T-Lymphocytes, Cytotoxic

Transfection

Viral Core Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 7679709
DOI: 10.1084/jem.177.3.751
PMCID: PMC2190933

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7679709-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HLA-A31- and HLA-Aw68-restricted cytotoxic T cell responses to a single hepatitis B virus nucleocapsid epitope during acute viral hepatitis.PMID 7679709Read ↗

A new unconventional HLA-A2-restricted epitope from HBV core protein elicits antiviral cytotoxic T lymphocytes.Semantic proximity Read ↗

Cytotoxic T lymphocyte response to a wild type hepatitis B virus epitope in patients chronically infected by variant viruses carrying substitutions within the epitope.Semantic proximity Read ↗

Characterization of sequence variations in immunodominant regions of the HBV-nucleocapsid protein as a prerequisite for the development of an epitope-based vaccine.Semantic proximity Read ↗

Immune escape pathways from the HBV core18-27 CD8 T cell response are driven by individual HLA class I alleles.Semantic proximity Read ↗

Three new cytotoxic T cell epitopes identified within the hepatitis C virus nucleoprotein.Semantic proximity Read ↗

Identification of hepatitis B virus-specific CTL epitopes presented by HLA-A*2402, the most common HLA class I allele in East Asia.Semantic proximity Read ↗

A systematic review of T-cell epitopes in hepatitis B virus: identification, genotypic variation and relevance to antiviral therapeutics.Semantic proximity Read ↗

An epitope in hepatitis C virus core region recognized by cytotoxic T cells in mice and humansSemantic proximity Read ↗

Discovery and Selection of Hepatitis B Virus-Derived T Cell Epitopes for Global Immunotherapy Based on Viral Indispensability, Conservation, and HLA-Binding Strength.Semantic proximity Read ↗

Identification of HLA-A3 and -B7-restricted CTL response to hepatitis C virus in patients with acute and chronic hepatitis C.Semantic proximity Read ↗

T cell receptor usage of virus-specific CD8 cells and recognition of viral mutations during acute and persistent hepatitis B virus infection.Semantic proximity Read ↗

Direct evidence that naturally occurring mutations within hepatitis B core epitope alter CD4+ T-cell reactivity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.