Article
NDK-1, the homolog of NM23-H1/H2 regulates cell migration and apoptotic engulfment in C. elegans.
PloS one - 1 Jan 2014
Fancsalszky Luca, Monostori Eszter, Farkas Zsolt, Pourkarimi Ehsan, Masoudi Neda, Hargitai Balázs, Bosnar Maja Herak, Deželjin Martina, Zsákai Annamária, Vellai Tibor, Mehta Anil, Takács-Vellai Krisztina
Abstract excerpt
Abnormal regulation of cell migration and altered rearrangement of cytoskeleton are characteristic of metastatic cells. The first described suppressor of metastatic processes is NM23-H1, which displays NDPK (nucleoside-diphosphate kinase) activity. To better understand the role of nm23 genes in cell migration, we investigated the function of NDK-1, the sole Caenorhabditis elegans homolog of group I NDPKs in...
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