Article
The dosage-dependent effect exerted by the NM23-H1/H2 homolog NDK-1 on distal tip cell migration in C. elegans.
Laboratory investigation; a journal of technical methods and pathology - 1 Feb 2018
Farkas Zsolt, Fancsalszky Luca, Saskői Éva, Gráf Alexandra, Tárnok Krisztián, Mehta Anil, Takács-Vellai Krisztina
Abstract excerpt
Abnormal regulation of cell migration and altered rearrangement of the cytoskeleton are fundamental properties of metastatic cells. The first identified metastasis suppressor NM23-H1, which displays nucleoside-diphosphate kinase (NDPK) activity is involved in these processes. NM23-H1 inhibits the migratory and invasive potential of some cancer cells. Correspondingly, numerous invasive cancer cell lines (eg,...
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