A longitudinal study of SLC6A4 DNA promoter methylation and poststroke depression.

doi:10.1016/j.jpsychires.2013.04.010

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Article

A longitudinal study of SLC6A4 DNA promoter methylation and poststroke depression.

Journal of psychiatric research - 1 Sept 2013

Kim Jae-Min, Stewart Robert, Kang Hee-Ju, Kim Sung-Wan, Shin Il-Seon, Kim Hye-Ran, Shin Myung-Geun, Kim Joon-Tae, Park Man-Seok, Cho Ki-Hyun, Yoon Jin-Sang

Abstract excerpt

Serotonin transporter gene (SLC6A4) has been shown to play an important role in the pathophysiology of mood disorders including poststroke depression (PSD). SLC6A4 expression is influenced by DNA methylation status and the SLC6A4 linked promoter region (5-HTTLPR) polymorphism. This study aimed to...

Topics

Aged
DNA Methylation
Depression
Female
Genetic Association Studies
Genotype
Humans
Logistic Models
Longitudinal Studies
Magnetic Resonance Imaging
Male
Middle Aged
Promoter Regions, Genetic
Psychiatric Status Rating Scales

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Serotonin Plasma Membrane Transport Proteins

Severity of Illness Index

Stroke

Tomography, X-Ray Computed

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Open in PubMed

Identifiers

PMID: 23702251
DOI: 10.1016/j.jpsychires.2013.04.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-23702251-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.