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Article

Non-HLA genes PTPN22, CDK6 and PADI4 are associated with specific autoantibodies in HLA-defined subgroups of rheumatoid arthritis.

Arthritis research & therapy - 20 Aug 2014

Snir Omri, Gomez-Cabrero David, Montes Ariana, Perez-Pampin Eva, Gómez-Reino Juan J, Seddighzadeh Maria, Klich Katharina U, Israelsson Lena, Ding Bo, Catrina Anca I, Holmdahl Rikard, Alfredsson Lars, Klareskog Lars, Tegnér Jesper, Gonzalez Antonio, Malmström Vivianne, Padyukov Leonid

Abstract excerpt

INTRODUCTION: Genetic susceptibility to complex diseases has been intensively studied during the last decade, yet only signals with small effect have been found leaving open the possibility that subgroups within complex traits show stronger association signals. In rheumatoid arthritis (RA), autoantibody production serves as a helpful discriminator in genetic studies and today anti-citrullinated cyclic peptide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25138370
DOI: 10.1186/s13075-014-0414-3
PMCID: PMC4292996

Genes

CDK6
PTPN22
PADI4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Non-HLA genes PTPN22, CDK6 and PADI4 are associated with specific autoantibodies in HLA-defined subgroups of rheumatoid arthritis.PMID 25138370Read ↗

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