Article
Image-guided intrathymic injection of multipotent stem cells supports lifelong T-cell immunity and facilitates targeted immunotherapy.
Blood - 1 May 2014
Tuckett Andrea Z, Thornton Raymond H, Shono Yusuke, Smith Odette M, Levy Emily R, Kreines Fabiana M, van den Brink Marcel R M, Zakrzewski Johannes L
Abstract excerpt
T-cell deficiency related to disease, medical treatment, or aging represents a major clinical challenge and is associated with significant morbidity and mortality in cancer and bone marrow transplantation recipients. This study describes several innovative and clinically relevant strategies to manipulate thymic function based on an interventional radiology technique for intrathymic injection of cells or drugs. We...
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