Article
Efficient intrathymic gene transfer following in situ administration of a rAAV serotype 8 vector in mice and nonhuman primates.
Molecular therapy : the journal of the American Society of Gene Therapy - 1 Mar 2009
Moreau Aurélie, Vicente Rita, Dubreil Laurence, Adjali Oumeya, Podevin Guillaume, Jacquet Chantal, Deschamps Jack Yves, Klatzmann David, Cherel Yan, Taylor Naomi, Moullier Philippe, Zimmermann Valérie S
Abstract excerpt
The thymus is the primary site of T-cell development and plays a key role in the induction of self-tolerance. We previously showed that the intrathymic (i.t.) injection of a transgene-expressing lentiviral vector (LV) in mice can result in the correction of a T cell-specific genetic defect. Nevertheless, the efficiency of thymocyte transduction did not exceed 0.1-0.3% and we were unable to detect any thymus...
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