Differentiation of hematopoietic stem cells in irradiated mouse thymic lobes. Kinetics and phenotype of progeny.

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Article

Differentiation of hematopoietic stem cells in irradiated mouse thymic lobes. Kinetics and phenotype of progeny.

Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 1990

Spangrude G J, Scollay R

Abstract excerpt

To define cell populations which participate in the very early stages of T cell development in the mouse thymus, we enriched hematopoietic stem cells from mouse bone marrow and injected them into thymic lobes of irradiated Ly-5 congenic recipients. The progeny of the stem cells were identified an...

Topics

Animals
Antigens, Differentiation, T-Lymphocyte
Antigens, Surface
CD4 Antigens
CD8 Antigens
Cell Differentiation
Hematopoietic Stem Cells
Histocompatibility Antigens Class I
Kinetics
Mice
Mice, Inbred C57BL
Phenotype
Receptors, Interleukin-2
T-Lymphocytes
Thymus Gland

Source

Open in PubMed

Identifiers

PMID: 2123223

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2123223-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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