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Article

SCN5A Variants: Association With Cardiac Disorders

9 Oct 2018

Abstract excerpt

The SCN5A gene encodes the alpha subunit of the main cardiac sodium channel Nav1.5. This channel predominates inward sodium current (INa) and plays a critical role in regulation of cardiac electrophysiological function. Since 1995, SCN5A variants have been found to be causatively associated with Brugada syndrome, long QT syndrome, cardiac conduction system dysfunction, dilated cardiomyopathy, etc. Previous...

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PMID: 30364184
DOI: 10.3389/fphys.2018.01372

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