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Article

Natural antisense transcripts regulate the neuronal stress response and excitability.

eLife - 1 Jan 2014

Zheng Xingguo, Valakh Vera, Diantonio Aaron, Ben-Shahar Yehuda

Abstract excerpt

Neurons regulate ionic fluxes across their plasma membrane to maintain their excitable properties under varying environmental conditions. However, the mechanisms that regulate ion channels abundance remain poorly understood. Here we show that pickpocket 29 (ppk29), a gene that encodes a Drosophila degenerin/epithelial sodium channel (DEG/ENaC), regulates neuronal excitability via a protein-independent mechanism....

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Identifiers

PMID: 24642409
DOI: 10.7554/eLife.01849
PMCID: PMC3953951

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