Article
A Drosophila behavioral mutant, down and out (dao), is defective in an essential regulator of Erg potassium channels.
Proceedings of the National Academy of Sciences of the United States of America - 23 Mar 2010
Fergestad Tim, Sale Harinath, Bostwick Bret, Schaffer Ashleigh, Ho Lingling, Robertson Gail A, Ganetzky Barry
Abstract excerpt
To signal properly, excitable cells must establish and maintain the correct balance of various types of ion channels that increase or decrease membrane excitability. The mechanisms by which this balance is regulated remain largely unknown. Here, we describe a regulatory mechanism uncovered by a Drosophila behavioral mutant, down and out (dao). At elevated temperatures, dao loss-of-function mutants exhibit...
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