Article
Pickpocket1 is an ionotropic molecular sensory transducer.
The Journal of biological chemistry - 16 Nov 2012
Boiko Nina, Kucher Volodymyr, Stockand James D, Eaton Benjamin A
Abstract excerpt
The molecular transformation of an external stimulus into changes in sensory neuron activity is incompletely described. Although a number of molecules have been identified that can respond to stimuli, evidence that these molecules can transduce stimulation into useful neural activity is lacking. Here we demonstrate that pickpocket1 (ppk1), a Drosophila homolog of mammalian Degenerin/epithelial sodium channels,...
Topics
- Action Potentials
- Animals
- Drosophila Proteins
- Drosophila melanogaster
- Mutation
- Nerve Tissue Proteins
- Sensory Receptor Cells
- Sodium Channels