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Article

A presynaptic ENaC channel drives homeostatic plasticity.

Neuron - 18 Sept 2013

Younger Meg A, Müller Martin, Tong Amy, Pym Edward C, Davis Graeme W

Abstract excerpt

An electrophysiology-based forward genetic screen has identified two genes, pickpocket11 (ppk11) and pickpocket16 (ppk16), as being necessary for the homeostatic modulation of presynaptic neurotransmitter release at the Drosophila neuromuscular junction (NMJ). Pickpocket genes encode Degenerin/Epithelial Sodium channel subunits (DEG/ENaC). We demonstrate that ppk11 and ppk16 are necessary in presynaptic...

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Identifiers

PMID: 23973209
DOI: 10.1016/j.neuron.2013.06.048
PMCID: PMC3784986

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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