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Article

Hepatic stellate cells orchestrate clearance of necrotic cells in a hypoxia-inducible factor-1α-dependent manner by modulating macrophage phenotype in mice.

Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 2014

Mochizuki Akie, Pace Aaron, Rockwell Cheryl E, Roth Katherine J, Chow Aaron, O'Brien Kate M, Albee Ryan, Kelly Kara, Towery Keara, Luyendyk James P, Copple Bryan L

Abstract excerpt

Hypoxia-inducible factor-1α (HIF-1α) is activated in hepatic stellate cells (HSCs) by hypoxia and regulates genes important for tissue repair. Whether HIF-1α is activated in HSCs after acute injury and contributes to liver regeneration, however, is not known. To investigate this, mice were genera...

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Identifiers

PMID: 24639359
DOI: 10.4049/jimmunol.1303195
PMCID: PMC4538924

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24639359-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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