Article
Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis.
Proceedings of the National Academy of Sciences of the United States of America - 12 Jun 2012
Kisseleva Tatiana, Cong Min, Paik Yonghan, Scholten David, Jiang Chunyan, Benner Chris, Iwaisako Keiko, Moore-Morris Thomas, Scott Brian, Tsukamoto Hidekazu, Evans Sylvia M, Dillmann Wolfgang, Glass Christopher K, Brenner David A
Abstract excerpt
Myofibroblasts produce the fibrous scar in hepatic fibrosis. In the carbon tetrachloride (CCl(4)) model of liver fibrosis, quiescent hepatic stellate cells (HSC) are activated to become myofibroblasts. When the underlying etiological agent is removed, clinical and experimental fibrosis undergoes a remarkable regression with complete disappearance of these myofibroblasts. Although some myofibroblasts apoptose, it...
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