Article
Using polymorphisms in FKBP5 to define biologically distinct subtypes of posttraumatic stress disorder: evidence from endocrine and gene expression studies.
Archives of general psychiatry - 1 Sept 2011
Mehta Divya, Gonik Mariya, Klengel Torsten, Rex-Haffner Monika, Menke Andreas, Rubel Jennifer, Mercer Kristina B, Pütz Benno, Bradley Bekh, Holsboer Florian, Ressler Kerry J, Müller-Myhsok Bertram, Binder Elisabeth B
Abstract excerpt
CONTEXT: Polymorphisms in the gene encoding the glucocorticoid receptor (GR) regulating co-chaperone FKBP5 have been shown to alter GR sensitivity and are associated with an increased risk to develop posttraumatic stress disorder (PTSD). OBJECTIVE: To investigate interactions of the FKBP5 single-nucleotide polymorphism rs9296158 and PTSD symptoms on baseline cortisol level, low-dose dexamethasone suppression, and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.