Article
Transcription factor NFAT5 contributes to the glycolytic phenotype rewiring and pancreatic cancer progression via transcription of PGK1.
Cell death & disease - 11 Dec 2019
Jiang Yongsheng, He Ruizhe, Jiang Yuhong, Liu Dejun, Tao Lingye, Yang Minwei, Lin Chaoyi, Shen Yang, Fu Xueliang, Yang Jianyu, Li Jiao, Huo Yanmiao, Hua Rong, Liu Wei, Zhang Junfeng, Shen Baiyong, Zhang Zhigang, Sun Yongwei
Abstract excerpt
Hypoxia and the hypovascular tumor microenvironment are major hallmarks of pancreatic ductal adenocarcinoma (PDAC), in which glycolysis is of great importance to tumor survival and proliferation. There is little research regarding the role of Nuclear Factor of Activated T Cells 5 (NFAT5) in relation to carcinoma. Here, we explored the impact of NFAT5 on the biological behavior of PDAC and the underlying...
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